CADM4

Across TCGA cell cohorts, CADM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,293 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CADM4-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Negative regulation of peptidyl-threonine phosphorylation, and Regulation of myoblast fusion. Each is linked with CADM4 in more than 14 cancer types. Because this analysis shows association rather than direction, both CADM4-to-partner and partner-to-CADM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by CADM4-low versus CADM4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CADM4→partner) and Y-score (partner→CADM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.114	+1.462	.003	.003	3	15
LIVER	Negative regulation of peptidyl-threonine phosphorylation →	+0.323	+2.569	<.001	<.001	3	14
STOMACH	Regulation of myoblast fusion →	+0.102	+1.825	.004	.009	2	15
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.135	+1.624	.002	<.001	3	14
KIDNEY	Negative regulation of calcium ion export across plasma membrane →	+0.064	+1.634	.003	.007	3	13
BLOOD_Lymphoma	Proton motive force-driven ATP synthesis →	+0.103	+0.896	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,293 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by CADM4 expression — OESOPHAGUS

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