CADM3

Across TCGA pan-cancer cohorts, CADM3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CADM3 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CADM3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CADM3 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

PDAC, GBM, and CCRCC are the cancer types where CADM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.295	0.654	.002	20	view →
GBM	DFS	Tertile	All	0.841	0.627	.020	4	view →
CCRCC	OS	Quartile	All	0.516	0.899	.024	4	view →
LSCC	OS	Median	All	0.669	0.859	.029	3	view →
HNSC	OS	Median	III,IV	0.962	0.815	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CADM3–PDAC (OS)

Open the PDAC breakdown →