CADM3

Across TCGA patient cohorts, CADM3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CADM3-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1_pS65, and FoxM1. Each is linked with CADM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both CADM3-to-partner and partner-to-CADM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CADM3-low versus CADM3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADM3→partner) and Y-score (partner→CADM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.178	+2.815	.006	.036	3	5
LUSC	4E-BP1_pS65 →	+0.218	+2.825	.001	.033	3	4
LUAD	FoxM1 →	+0.286	+3.203	.007	.008	3	3
LUAD	PDK1_pS241 →	-0.183	-3.169	.015	.018	3	2
SKCM	Chk1_pS345 →	+0.148	+2.906	.001	.001	3	2
UCEC	Ku80 →	+0.203	+1.598	.017	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by CADM3 expression — COAD

Explore this box plot interactively →