CADM2

Across TCGA pan-cancer cohorts, CADM2 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CADM2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CADM2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CADM2 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD and HNSC are the cancer types where CADM2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CADM2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−1.796	<.001	6	view →
HNSC	All	All	−1.327	.012	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

CADM2–COAD

Open the COAD breakdown →