CADM2

Across TCGA patient cohorts, CADM2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CADM2-associated genes across cancer lineages are Cyclin-B1, TFRC, and eIF4E. Each is linked with CADM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CADM2-to-partner and partner-to-CADM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CADM2-low versus CADM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADM2→partner) and Y-score (partner→CADM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.602	+4.000	.001	<.001	3	3
UCEC	TFRC →	+0.374	+2.000	.032	.029	3	3
UCEC	eIF4E →	+0.173	+3.472	.012	.002	3	2
UCEC	p27_pT198 →	+0.069	+2.321	.049	.005	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.331	-1.584	.025	.034	3	2
UCEC	PCNA →	+0.161	+1.906	.024	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Cyclin-B1 by CADM2 expression — UCEC

Explore this box plot interactively →