CADM1

Across TCGA patient cohorts, CADM1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CADM1-associated genes across cancer lineages are TFRC, Rictor_pT1135, and Smad4. Each is linked with CADM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CADM1-to-partner and partner-to-CADM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by CADM1-low versus CADM1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADM1→partner) and Y-score (partner→CADM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TFRC →	+0.723	+3.321	.013	.010	3	4
COAD	Rictor_pT1135 →	-0.165	-2.674	.002	.006	3	3
COAD	Smad4 →	+0.111	+3.321	.038	.009	3	3
COAD	Caspase-7-cleavedD198 →	+1.594	+2.708	<.001	.003	2	4
UCEC	4E-BP1 →	+0.375	+3.837	<.001	<.001	3	3
UCEC	A-Raf_pS299 →	-0.141	-1.906	<.001	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

TFRC by CADM1 expression — STAD

Explore this box plot interactively →