CADM1

Across TCGA cell cohorts, CADM1 mutation is significantly associated with the RNA expression of many other genes, with 90 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CADM1-associated genes across cancer lineages are OR2AJ1, EBF2, and NKX2-4. Each is linked with CADM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CADM1-to-partner and partner-to-CADM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by CADM1-low versus CADM1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADM1→partner) and Y-score (partner→CADM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2AJ1 →	+0.015	+3.734	<.001	.006	3	2
BLOOD_Leukemia	EBF2 →	+0.195	+3.551	<.001	.008	3	2
LUNG_NSCLC_LUAD	NKX2-4 →	+0.819	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	GFRA4 →	+0.021	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR5B2 →	+0.023	+4.481	.008	.001	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.025	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

OR2AJ1 by CADM1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →