CACUL1

Across TCGA pan-cancer cohorts, CACUL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CACUL1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CACUL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CACUL1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where CACUL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	III,IV	1.000	0.239	.013	13	view →
PDAC	DFS	Tertile	All	0.738	0.917	.013	12	view →
CCRCC	OS	Quartile	All	0.821	1.000	.010	7	view →
HNSC	DFS	Tertile	III,IV	1.000	0.892	.016	3	view →
LSCC	DFS	Tertile	II,III,IV	0.966	0.855	.043	2	view →
GBM	OS	Quartile	All	0.760	0.946	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CACUL1–LUAD (DFS)

Open the LUAD breakdown →