CACUL1

Across TCGA patient cohorts, CACUL1 mutation is significantly associated with the RNA expression of many other genes, with 2,603 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACUL1-associated genes across cancer lineages are SPATA16, EME1, and MIS18A. Each is linked with CACUL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACUL1-to-partner and partner-to-CACUL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA16 grouped by CACUL1-low versus CACUL1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACUL1→partner) and Y-score (partner→CACUL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SPATA16 →	+0.109	+3.816	<.001	.007	3	2
UCEC	EME1 →	+0.609	+2.627	<.001	.005	3	2
UCEC	MIS18A →	+0.596	+2.721	<.001	.003	3	2
UCEC	CDC25A →	+0.672	+3.111	<.001	<.001	3	2
UCEC	PTTG1 →	+0.664	+3.595	.002	.001	3	2
UCEC	LEO1 →	+0.392	+3.831	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,603 associations by consensus.

SPATA16 by CACUL1 expression — CESC

Explore this box plot interactively →