CACNG8

Across TCGA patient cohorts, CACNG8 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNG8-associated genes across cancer lineages are DJ-1, Notch1, and Annexin-1. Each is linked with CACNG8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNG8-to-partner and partner-to-CACNG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DJ-1 grouped by CACNG8-low versus CACNG8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNG8→partner) and Y-score (partner→CACNG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DJ-1 →	+0.216	+3.000	.025	.037	2	3
UCEC	Notch1 →	+0.214	+2.817	.008	.036	3	1
UCEC	Annexin-1 →	+0.744	+3.000	.014	.037	3	1
UCEC	4E-BP1_pT70 →	+0.146	+3.000	.028	.037	3	1
UCEC	PDCD4 →	-0.733	-3.000	.007	.037	2	1
UCEC	4E-BP1 →	+0.562	+3.000	<.001	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

DJ-1 by CACNG8 expression — UCEC

Explore this box plot interactively →