CACNG5

Across TCGA patient cohorts, CACNG5 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNG5-associated genes across cancer lineages are EGFR_pY1068, CD31, and p27_pT198. Each is linked with CACNG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNG5-to-partner and partner-to-CACNG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CACNG5-low versus CACNG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNG5→partner) and Y-score (partner→CACNG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.328	-3.459	.003	.005	3	3
UCEC	CD31 →	-0.154	-2.311	.020	.034	3	3
UCEC	p27_pT198 →	+0.105	+2.000	.030	.032	3	2
UCEC	PEA-15_pS116 →	+0.347	+2.000	.028	.032	3	2
UCEC	STAT3_pY705 →	-0.526	-3.449	<.001	.005	3	2
UCEC	VHL →	-1.017	-2.000	<.001	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

EGFR_pY1068 by CACNG5 expression — UCEC

Explore this box plot interactively →