CACNG4

Across TCGA pan-cancer cohorts, CACNG4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CACNG4 data layer compared with 29 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CACNG4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CACNG4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

SKCM, LUSC, and UCEC are the cancer types where CACNG4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	1.000	0.556	.007	17	view →
LUSC	DFS	Median	All	0.232	0.759	.001	9	view →
UCEC	DFS	Median	II,III,IV	0.922	0.437	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CACNG4–SKCM (DFS)

Open the SKCM breakdown →