CACNG4

Across TCGA patient cohorts, CACNG4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNG4-associated genes across cancer lineages are eEF2, Notch1, and Chk2_pT68. Each is linked with CACNG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNG4-to-partner and partner-to-CACNG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CACNG4-low versus CACNG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNG4→partner) and Y-score (partner→CACNG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.345	+1.874	.008	.049	3	2
UCEC	Notch1 →	+0.169	+2.125	.001	.010	3	2
UCEC	Chk2_pT68 →	-0.165	-3.433	.016	.005	3	2
UCEC	c-Jun_pS73 →	-0.117	-1.990	.044	.030	3	2
UCEC	EGFR_pY1068 →	-0.209	-1.847	.023	.008	3	1
UCEC	eIF4E →	+0.160	+3.335	.039	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eEF2 by CACNG4 expression — UCEC

Explore this box plot interactively →