CACNG1

Across TCGA pan-cancer cohorts, CACNG1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CACNG1 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CACNG1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CACNG1 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

CESC, PRAD, and STAD are the cancer types where CACNG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.173	0.740	.003	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
STAD	OS	Median	III,IV	0.003	0.630	<.001	6	view →
LIHC	OS	Median	All	0.258	0.773	.018	6	view →
LUSC	OS	Median	All	0.081	0.818	<.001	6	view →
COAD	DFS	Median	II,III,IV	1.000	0.648	.027	2	view →
UCEC	DFS	Median	All	1.000	0.630	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CACNG1–CESC (DFS)

Open the CESC breakdown →