CACNB2

Across TCGA cell cohorts, CACNB2 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNB2-associated genes across cancer lineages are KLHL40, SIGLEC5, and FBXO40. Each is linked with CACNB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNB2-to-partner and partner-to-CACNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by CACNB2-low versus CACNB2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNB2→partner) and Y-score (partner→CACNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	2
SKIN	SIGLEC5 →	+0.022	+4.415	<.001	.007	3	2
OESOPHAGUS	FBXO40 →	+0.013	+4.017	.002	.007	3	1
OESOPHAGUS	OR51B6 →	+0.187	+4.017	.008	.007	3	1
OESOPHAGUS	TMEM202 →	+0.096	+4.392	<.001	.003	3	1
PANCREAS	CCDC182 →	+0.023	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

KLHL40 by CACNB2 expression — BLOOD_Lymphoma

Explore this box plot interactively →