CACNB1

Across TCGA patient cohorts, CACNB1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNB1-associated genes across cancer lineages are VHL, eIF4E, and HSP70. Each is linked with CACNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNB1-to-partner and partner-to-CACNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CACNB1-low versus CACNB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNB1→partner) and Y-score (partner→CACNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.720	-1.643	<.001	.002	3	2
UCEC	eIF4E →	+0.127	+1.584	.040	.034	3	1
UCEC	HSP70 →	-0.236	-1.352	.046	.034	3	1
UCEC	INPP4B →	-0.190	-2.087	.045	.004	3	1
UCEC	JNK2 →	+0.169	+1.290	.003	.034	3	1
UCEC	Ku80 →	+0.210	+1.594	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

VHL by CACNB1 expression — UCEC

Explore this box plot interactively →