CACNA2D3

Across TCGA pan-cancer cohorts, CACNA2D3 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated CACNA2D3 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CACNA2D3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CACNA2D3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, READ, and UCEC are the cancer types where CACNA2D3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	IV	0.342	0.893	<.001	24	view →
READ	OS	Median	III,IV	0.234	0.805	<.001	22	view →
UCEC	DFS	Median	III,IV	0.922	0.517	.014	16	view →
ESCA	OS	Median	All	0.198	0.872	.003	12	view →
SARC	OS	Median	All	0.239	0.826	.002	9	view →
PRAD	DFS	Median	All	0.425	0.888	<.001	6	view →
BLCA	OS	Median	III,IV	0.051	0.684	<.001	6	view →
LIHC	OS	Median	All	0.252	0.674	.022	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CACNA2D3–LUAD (DFS)

Open the LUAD breakdown →