CACNA2D3

Across TCGA patient cohorts, CACNA2D3 protein abundance is significantly associated with the RNA expression of many other genes, with 3,498 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CACNA2D3-associated genes across cancer lineages are SNRPD3, PRODH, and GRK3. Each is linked with CACNA2D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNA2D3-to-partner and partner-to-CACNA2D3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CACNA2D3 versus SNRPD3 in GBM, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D3→partner) and Y-score (partner→CACNA2D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPD3 →	+0.351	+0.460	.001	<.001	3	1
GBM	PRODH →	+1.223	+0.590	<.001	<.001	3	1
GBM	GRK3 →	+0.399	+0.538	.007	<.001	3	1
GBM	SEZ6L →	+1.302	+0.387	.003	.003	3	1
GBM	SOX10 →	+1.404	+0.607	<.001	<.001	3	1
GBM	SLC16A8 →	+0.591	+0.440	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,498 associations by consensus.

CACNA2D3 vs SNRPD3 — GBM

Explore this scatter interactively →