CACNA2D3

Across TCGA patient cohorts, CACNA2D3 mutation is significantly associated with the RNA expression of many other genes, with 5,947 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA2D3-associated genes across cancer lineages are H4C2, RNU6-77P, and LINC01809. Each is linked with CACNA2D3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CACNA2D3-to-partner and partner-to-CACNA2D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H4C2 grouped by CACNA2D3-low versus CACNA2D3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D3→partner) and Y-score (partner→CACNA2D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	H4C2 →	+1.006	+3.817	<.001	<.001	3	4
STAD	RNU6-77P →	+0.328	+2.450	.007	.001	3	4
STAD	LINC01809 →	+0.203	+1.847	.002	.009	3	4
UCEC	H2AC12 →	+0.596	+1.506	<.001	<.001	3	3
UCEC	MIR7976 →	+0.272	+1.389	<.001	.004	3	3
UCEC	H4C5 →	+0.544	+1.687	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,947 associations by consensus.

H4C2 by CACNA2D3 expression — COAD

Explore this box plot interactively →