CACNA2D3

Across TCGA cell cohorts, CACNA2D3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,259 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CACNA2D3-associated GO terms across cancer lineages are Oxidative phosphorylation, Primary heart field specification, and Nucleoside triphosphate biosynthetic process. Each is linked with CACNA2D3 in more than 9 cancer types. Because this analysis shows association rather than direction, both CACNA2D3-to-partner and partner-to-CACNA2D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative phosphorylation grouped by CACNA2D3-low versus CACNA2D3-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D3→partner) and Y-score (partner→CACNA2D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Oxidative phosphorylation →	+0.061	+0.604	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Primary heart field specification →	+1.369	+1.791	.001	<.001	3	9
PANCREAS	Nucleoside triphosphate biosynthetic process →	+0.052	+0.181	.003	.007	3	9
SKIN	Purine nucleoside triphosphate biosynthetic process →	+0.070	+0.661	<.001	.006	3	9
PANCREAS	Ribonucleoside triphosphate biosynthetic process →	+0.053	+0.181	.002	.007	3	9
SKIN	Purine ribonucleoside triphosphate biosynthetic process →	+0.070	+0.661	<.001	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,259 associations by consensus.

Oxidative phosphorylation by CACNA2D3 expression — SKIN

Explore this box plot interactively →