CACNA2D3

Across TCGA cell cohorts, CACNA2D3 mutation is significantly associated with the RNA expression of many other genes, with 1,126 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA2D3-associated genes across cancer lineages are FBXL4, IFT27, and DDHD1. Each is linked with CACNA2D3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNA2D3-to-partner and partner-to-CACNA2D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXL4 grouped by CACNA2D3-low versus CACNA2D3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D3→partner) and Y-score (partner→CACNA2D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXL4 →	+0.564	+2.949	<.001	<.001	3	3
LARGE_INTESTINE	IFT27 →	+0.790	+3.523	.001	<.001	3	2
LARGE_INTESTINE	DDHD1 →	+0.621	+2.265	.003	.001	3	2
LARGE_INTESTINE	FIG4 →	+0.553	+3.459	<.001	.001	3	2
LARGE_INTESTINE	SLC25A12 →	+0.536	+2.265	.002	.001	3	2
LARGE_INTESTINE	NEK9 →	+0.649	+3.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,126 associations by consensus.

FBXL4 by CACNA2D3 expression — LARGE_INTESTINE

Explore this box plot interactively →