CACNA2D2

Across TCGA pan-cancer cohorts, CACNA2D2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CACNA2D2 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CACNA2D2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CACNA2D2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

THYM, UCEC, and PRAD are the cancer types where CACNA2D2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	II,III,IV	0.946	0.298	.002	32	view →
PRAD	DFS	Median	All	0.085	0.776	<.001	12	view →
STAD	DFS	Median	III,IV	1.000	0.334	.041	2	view →
SKCM	DFS	Median	All	0.095	0.215	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CACNA2D2–THYM (OS)

Open the THYM breakdown →