CACNA2D2

Across TCGA patient cohorts, CACNA2D2 mutation is significantly associated with the RNA expression of many other genes, with 1,657 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA2D2-associated genes across cancer lineages are RNA5SP461, RNU6-338P, and NKX2-6. Each is linked with CACNA2D2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CACNA2D2-to-partner and partner-to-CACNA2D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP461 grouped by CACNA2D2-low versus CACNA2D2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D2→partner) and Y-score (partner→CACNA2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP461 →	+0.044	+3.772	<.001	.005	3	4
BRCA	RNU6-338P →	+0.295	+5.786	<.001	.001	3	3
KIRP	NKX2-6 →	+0.122	+5.159	<.001	.007	3	3
HNSC	OR6B1 →	+0.087	+5.497	<.001	<.001	3	3
HNSC	RNU6-1234P →	+0.266	+5.023	<.001	.003	3	3
UCEC	HINT1P1 →	+0.373	+1.797	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,657 associations by consensus.

RNA5SP461 by CACNA2D2 expression — SKCM

Explore this box plot interactively →