CACNA2D2

Across TCGA patient cohorts, CACNA2D2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA2D2-associated genes across cancer lineages are Cyclin-B1, NDRG1_pT346, and TSC1. Each is linked with CACNA2D2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNA2D2-to-partner and partner-to-CACNA2D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CACNA2D2-low versus CACNA2D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D2→partner) and Y-score (partner→CACNA2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.585	+2.087	.001	.005	3	3
SKCM	NDRG1_pT346 →	-0.549	-1.662	.018	.011	3	2
SKCM	TSC1 →	-0.186	-1.362	.010	.035	3	2
SKCM	DJ-1 →	+0.191	+1.680	.002	.006	3	2
UCEC	GAPDH →	+0.412	+2.000	.016	.029	3	2
UCEC	mTOR_pS2448 →	-0.108	-1.565	.023	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Cyclin-B1 by CACNA2D2 expression — UCEC

Explore this box plot interactively →