CACNA2D2

Across TCGA cell cohorts, CACNA2D2 mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA2D2-associated genes across cancer lineages are OR8B4, MBD3L5, and NKX2-6. Each is linked with CACNA2D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNA2D2-to-partner and partner-to-CACNA2D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B4 grouped by CACNA2D2-low versus CACNA2D2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D2→partner) and Y-score (partner→CACNA2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	1
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	1
BLOOD_Leukemia	NKX2-6 →	+0.489	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	WFDC11 →	+0.030	+4.539	<.001	.007	3	1
BLOOD_Leukemia	FAM24A →	+0.064	+4.969	<.001	.003	3	1
BLOOD_Leukemia	OR1D4 →	+0.046	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

OR8B4 by CACNA2D2 expression — OESOPHAGUS

Explore this box plot interactively →