CACNA2D1

Across TCGA pan-cancer cohorts, CACNA2D1 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated CACNA2D1 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CACNA2D1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CACNA2D1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, THCA, and UCEC are the cancer types where CACNA2D1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
THCA	DFS	Median	All	0.087	0.896	<.001	24	view →
UCEC	DFS	Median	All	0.930	0.606	.009	22	view →
COAD	OS	Median	III,IV	0.056	0.793	<.001	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
BLCA	OS	Median	III,IV	0.129	0.588	<.001	6	view →
PRAD	DFS	Median	All	0.153	0.888	<.001	6	view →
LUAD	OS	Median	III,IV	0.202	0.688	.002	6	view →
HNSC	OS	Median	All	0.542	0.757	.013	3	view →
SKCM	OS	Median	All	0.523	0.788	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

CACNA2D1–ACC (DFS)

Open the ACC breakdown →