CACNA2D1

Across TCGA pan-cancer cohorts, CACNA2D1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CACNA2D1 data layer compared with 24 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CACNA2D1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CACNA2D1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where CACNA2D1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.743	0.505	.007	14	view →
HNSC	OS	Tertile	III,IV	0.339	1.000	.020	13	view →
PDAC	OS	Tertile	IV	0.916	0.231	.024	6	view →
CCRCC	OS	Quartile	III,IV	0.047	0.977	.038	6	view →
LSCC	DFS	Median	II,III,IV	0.999	0.848	.013	4	view →
GBM	DFS	Quartile	All	0.873	0.723	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CACNA2D1–LUAD (DFS)

Open the LUAD breakdown →