Across TCGA cell cohorts, CACNA1H mutation is significantly associated with the RNA expression of many other genes, with 2,437 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA1H-associated genes across cancer lineages are PAQR3, NPIPB6, and MTF2. Each is linked with CACNA1H in more than 3 cancer types. Because this analysis shows association rather than direction, both CACNA1H-to-partner and partner-to-CACNA1H results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1H→partner) and Y-score (partner→CACNA1H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PAQR3 →	+0.708	+2.290	<.001	<.001	3	4
BLOOD_Lymphoma	NPIPB6 →	+0.997	+3.395	<.001	.002	3	4
SKIN	MTF2 →	+0.419	+3.234	.003	.004	3	3
SKIN	FCGR2A →	-1.819	-2.455	.003	.006	3	3
LARGE_INTESTINE	LYG1 →	+1.052	+2.780	<.001	<.001	3	3
STOMACH	ENOPH1 →	+0.608	+2.137	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,437 associations by consensus.

Exploration

CACNA1H survival (RNA) · tumor vs normal (RNA) · all CACNA1H data types