CACNA1D

Across TCGA pan-cancer cohorts, CACNA1D Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CACNA1D data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CACNA1D Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CACNA1D expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, BLCA, and ESCA are the cancer types where CACNA1D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.925	0.593	<.001	34	view →
BLCA	OS	Median	II,III,IV	0.780	0.404	.004	29	view →
ESCA	OS	Median	II,III,IV	0.233	0.707	<.001	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LGG	DFS	Median	All	0.326	0.835	<.001	10	view →
BRCA	OS	Median	II,III,IV	0.316	0.570	.014	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	5	view →
SARC	DFS	Median	All	0.102	0.348	.016	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CACNA1D–UCEC (DFS)

Open the UCEC breakdown →