CACNA1D

Across TCGA patient cohorts, CACNA1D mutation is significantly associated with the total protein of many other genes, with 88 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA1D-associated genes across cancer lineages are eEF2, eIF4E, and FASN. Each is linked with CACNA1D in more than 3 cancer types. Because this analysis shows association rather than direction, both CACNA1D-to-partner and partner-to-CACNA1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CACNA1D-low versus CACNA1D-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1D→partner) and Y-score (partner→CACNA1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eEF2 →	+0.379	+3.000	.001	.033	3	4
STAD	eIF4E →	+0.159	+2.115	.025	.017	3	4
STAD	FASN →	+0.410	+3.600	.012	.001	3	4
STAD	Annexin_VII →	-0.157	-2.321	.015	.032	3	4
STAD	4E-BP1 →	+0.312	+2.321	.007	.032	3	4
COAD	Cyclin-E2 →	+0.223	+3.832	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

eEF2 by CACNA1D expression — STAD

Explore this box plot interactively →