CACNA1D

Across TCGA cell cohorts, CACNA1D RNA expression is significantly associated with the go_rna of many other GO terms, with 4,192 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CACNA1D-associated GO terms across cancer lineages are Regulation of atrial cardiac muscle cell membrane repolarization, Dentinogenesis, and Positive regulation of lyase activity. Each is linked with CACNA1D in more than 17 cancer types. Because this analysis shows association rather than direction, both CACNA1D-to-partner and partner-to-CACNA1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of atrial cardiac muscle cell membrane repolarization grouped by CACNA1D-low versus CACNA1D-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1D→partner) and Y-score (partner→CACNA1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of atrial cardiac muscle cell membrane repolarization →	-0.362	-1.819	.002	.002	3	18
LUNG_NSCLC_LUAD	Dentinogenesis →	-1.677	-1.476	<.001	<.001	3	10
STOMACH	Positive regulation of lyase activity →	-0.169	-2.123	<.001	<.001	3	9
STOMACH	Positive regulation of cyclase activity →	-0.140	-1.625	.001	<.001	3	9
OVARY	Morphogenesis of an epithelial fold →	+1.050	+0.846	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Neutrophil extravasation →	-0.395	-0.976	.007	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,192 associations by consensus.

Regulation of atrial cardiac muscle cell membrane repolarization by CACNA1D expression — STOMACH

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