CACNA1D

Across TCGA cell cohorts, CACNA1D mutation is significantly associated with the RNA expression of many other genes, with 1,123 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA1D-associated genes across cancer lineages are PPP2R5E, ZBTB14, and ACTR6. Each is linked with CACNA1D in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNA1D-to-partner and partner-to-CACNA1D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R5E grouped by CACNA1D-low versus CACNA1D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1D→partner) and Y-score (partner→CACNA1D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP2R5E →	+0.421	+3.321	.006	.003	3	3
LARGE_INTESTINE	ZBTB14 →	+0.440	+2.158	<.001	.004	3	3
LARGE_INTESTINE	ACTR6 →	+0.609	+2.936	<.001	<.001	3	3
LARGE_INTESTINE	SIRT1 →	+0.699	+2.649	<.001	.001	3	3
BLOOD_Leukemia	YY1 →	+0.484	+2.614	.001	.003	3	3
BLOOD_Leukemia	AKAP3 →	+0.596	+3.285	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,123 associations by consensus.

PPP2R5E by CACNA1D expression — LARGE_INTESTINE

Explore this box plot interactively →