CACNA1C-AS3

Across TCGA pan-cancer cohorts, CACNA1C-AS3 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated CACNA1C-AS3 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher CACNA1C-AS3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CACNA1C-AS3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ESCA show a favorable association.

MESO, BLCA, and TGCT are the cancer types where CACNA1C-AS3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.069	0.580	<.001	99	view →
BLCA	OS	Tertile	IV	0.074	0.599	<.001	63	view →
TGCT	DFS	Tertile	All	0.437	0.824	<.001	54	view →
SKCM	DFS	Tertile	III,IV	0.052	0.616	<.001	45	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
STAD	OS	Tertile	All	0.353	0.584	.014	36	view →
OV	DFS	Tertile	IV	0.177	0.479	.025	30	view →
UCEC	OS	Tertile	All	0.808	0.930	.021	30	view →
LUAD	DFS	Tertile	All	0.701	0.322	.018	27	view →
KIRC	DFS	Tertile	IV	0.299	0.520	.015	24	view →
ESCA	OS	Tertile	III,IV	0.697	0.355	.023	21	view →
PCPG	DFS	Tertile	All	0.687	0.909	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

CACNA1C-AS3–MESO (OS)

Open the MESO breakdown →