CACNA1A

Across TCGA pan-cancer cohorts, CACNA1A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated CACNA1A data layer compared with 24 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher CACNA1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CACNA1A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

THCA, ACC, and BRCA are the cancer types where CACNA1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.098	0.941	<.001	42	view →
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
BRCA	OS	Median	III,IV	0.111	0.551	<.001	26	view →
UCEC	DFS	Median	III,IV	0.875	0.513	.016	20	view →
LGG	OS	Median	All	0.182	0.909	<.001	12	view →
SCLC	DFS	Median	IV	1.000	0.192	.026	11	view →
SKCM	OS	Median	III,IV	0.582	0.854	.001	7	view →
OV	OS	Median	IV	0.170	0.758	.044	6	view →
SARC	OS	Median	All	0.116	0.490	.032	6	view →
ESCA	OS	Median	All	0.147	0.700	.002	6	view →
LUAD	DFS	Median	IV	0.671	0.893	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

CACNA1A–THCA (OS)

Open the THCA breakdown →