CACNA1A

Across TCGA patient cohorts, CACNA1A mutation is significantly associated with the total protein of many other genes, with 105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA1A-associated genes across cancer lineages are 4E-BP1, MYH11, and PDCD4. Each is linked with CACNA1A in more than 4 cancer types. Because this analysis shows association rather than direction, both CACNA1A-to-partner and partner-to-CACNA1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CACNA1A-low versus CACNA1A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1A→partner) and Y-score (partner→CACNA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.316	+3.321	.007	.009	3	5
SKCM	MYH11 →	-0.451	-1.362	.040	.028	3	5
LUAD	PDCD4 →	-0.461	-1.983	.003	.009	3	4
LUAD	Stathmin →	+0.271	+1.999	<.001	.029	3	4
STAD	Caveolin-1 →	-1.035	-3.584	<.001	.002	2	5
LUAD	Chk1 →	+0.414	+2.459	<.001	.017	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

4E-BP1 by CACNA1A expression — STAD

Explore this box plot interactively →