CACNA1A

Across TCGA cell cohorts, CACNA1A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,982 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CACNA1A-associated GO terms across cancer lineages are Regulation of cardiac muscle adaptation, Regulation of cardiac muscle hypertrophy in response to stress, and Thiamine transmembrane transport. Each is linked with CACNA1A in more than 6 cancer types. Because this analysis shows association rather than direction, both CACNA1A-to-partner and partner-to-CACNA1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cardiac muscle adaptation grouped by CACNA1A-low versus CACNA1A-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1A→partner) and Y-score (partner→CACNA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of cardiac muscle adaptation →	+0.246	+0.941	.001	.009	3	7
BREAST	Regulation of cardiac muscle hypertrophy in response to stress →	+0.246	+0.941	.001	.009	3	7
UPPER_AERODIGESTIVE_TRACT	Thiamine transmembrane transport →	-0.897	-0.337	.005	.001	3	6
BLOOD_Myeloma	Modified amino acid transport →	-0.091	-1.997	.001	.008	3	6
BREAST	Regulation of cell-substrate junction assembly →	+0.071	+0.433	.004	.004	2	7
BLOOD_Leukemia	Positive regulation of plasma membrane repair →	+0.237	+0.555	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,982 associations by consensus.

Regulation of cardiac muscle adaptation by CACNA1A expression — BREAST

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