CACNA1A

Across TCGA cell cohorts, CACNA1A mutation is significantly associated with the RNA expression of many other genes, with 446 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA1A-associated genes across cancer lineages are ENHO, CALHM4, and OR5P2. Each is linked with CACNA1A in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNA1A-to-partner and partner-to-CACNA1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENHO grouped by CACNA1A-low versus CACNA1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1A→partner) and Y-score (partner→CACNA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ENHO →	+0.552	+1.275	.001	.009	3	3
BLOOD_Lymphoma	CALHM4 →	+0.185	+2.765	<.001	.007	3	2
BLOOD_Lymphoma	OR5P2 →	+0.015	+3.130	<.001	.006	3	2
BREAST	OR10J1 →	+0.283	+3.781	.002	.009	3	2
BLOOD_Leukemia	MSTN →	+0.233	+3.383	.002	.007	3	2
BLOOD_Leukemia	NPFFR1 →	+0.008	+3.359	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 446 associations by consensus.

ENHO by CACNA1A expression — LARGE_INTESTINE

Explore this box plot interactively →