CACHD1

Across TCGA pan-cancer cohorts, CACHD1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CACHD1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CACHD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CACHD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, PDAC, and OV are the cancer types where CACHD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.782	0.413	.005	20	view →
PDAC	DFS	Median	II,III,IV	0.655	0.925	.015	11	view →
OV	DFS	Median	All	0.671	1.000	.025	8	view →
LSCC	DFS	Median	All	0.616	0.806	.014	7	view →
GBM	OS	Median	All	0.234	0.556	.002	5	view →
UCEC	DFS	Tertile	II,III,IV	0.512	0.902	.040	4	view →
HNSC	OS	Quartile	II,III,IV	0.747	0.955	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CACHD1–LUAD (DFS)

Open the LUAD breakdown →