CACHD1

Across TCGA patient cohorts, CACHD1 mutation is significantly associated with the RNA expression of many other genes, with 6,930 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACHD1-associated genes across cancer lineages are ATF1, GOT2, and CLEC4E. Each is linked with CACHD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CACHD1-to-partner and partner-to-CACHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF1 grouped by CACHD1-low versus CACHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACHD1→partner) and Y-score (partner→CACHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATF1 →	+0.455	+1.583	<.001	<.001	3	4
UCEC	GOT2 →	+0.614	+2.150	<.001	<.001	3	4
SKCM	CLEC4E →	+0.724	+2.321	.002	.005	3	4
UCEC	CCL4 →	+0.954	+2.150	<.001	<.001	3	3
SKCM	KIR3DX1 →	+0.138	+1.744	<.001	.005	3	3
SKCM	RHCG →	-1.178	-1.906	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,930 associations by consensus.

ATF1 by CACHD1 expression — UCEC

Explore this box plot interactively →