CACHD1

Across TCGA patient cohorts, CACHD1 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACHD1-associated genes across cancer lineages are Rab25, Caveolin-1, and GAPDH. Each is linked with CACHD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CACHD1-to-partner and partner-to-CACHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by CACHD1-low versus CACHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACHD1→partner) and Y-score (partner→CACHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.253	-2.000	.015	.009	3	4
SKCM	Caveolin-1 →	-0.501	-1.807	.049	.026	3	3
UCEC	GAPDH →	+0.369	+1.765	.029	.013	3	3
UCEC	N-Cadherin →	+0.134	+1.700	.045	.040	3	3
COAD	ATM →	-0.549	-1.991	<.001	.009	3	3
COAD	eEF2 →	+0.263	+2.222	.011	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Rab25 by CACHD1 expression — UCEC

Explore this box plot interactively →