CACHD1

Across TCGA cell cohorts, CACHD1 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACHD1-associated genes across cancer lineages are NEUROD6, TFDP3, and OR14J1. Each is linked with CACHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACHD1-to-partner and partner-to-CACHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROD6 grouped by CACHD1-low versus CACHD1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACHD1→partner) and Y-score (partner→CACHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NEUROD6 →	+2.121	+3.380	<.001	.008	3	2
BLOOD_Lymphoma	TFDP3 →	+0.190	+3.523	<.001	.009	3	2
BREAST	OR14J1 →	+0.020	+5.781	<.001	.001	3	1
LARGE_INTESTINE	SH3GL2 →	+1.435	+3.474	<.001	.003	3	1
LARGE_INTESTINE	PAIP2B →	+0.880	+3.067	.001	.009	3	1
LARGE_INTESTINE	PPA2 →	+0.717	+3.064	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

NEUROD6 by CACHD1 expression — LUNG_SCLC

Explore this box plot interactively →