CACFD1

Across TCGA pan-cancer cohorts, CACFD1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CACFD1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CACFD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CACFD1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where CACFD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.566	1.000	.001	27	view →
CCRCC	OS	Tertile	II,III,IV	0.985	0.104	.024	8	view →
PDAC	OS	Median	II,III,IV	1.000	0.290	.049	5	view →
LUAD	OS	Median	All	0.509	0.911	.025	4	view →
GBM	DFS	Median	All	0.469	0.317	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CACFD1–LSCC (DFS)

Open the LSCC breakdown →