CACFD1

Across TCGA patient cohorts, CACFD1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACFD1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with CACFD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACFD1-to-partner and partner-to-CACFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CACFD1-low versus CACFD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACFD1→partner) and Y-score (partner→CACFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.143	-2.301	.002	.034	3	1
UCEC	EGFR_pY1068 →	-0.233	-2.584	.047	.011	3	1
UCEC	A-Raf_pS299 →	-0.158	-2.321	.004	.034	3	1
UCEC	INPP4B →	-0.314	-3.169	.037	.019	3	1
UCEC	MEK1 →	+0.477	+3.169	.005	.019	3	1
UCEC	p62 Lck ligand →	+0.469	+3.710	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

14-3-3_beta by CACFD1 expression — UCEC

Explore this box plot interactively →