CABLES1

Across TCGA pan-cancer cohorts, CABLES1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CABLES1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CABLES1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CABLES1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where CABLES1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.527	0.283	<.001	65	view →
CCRCC	DFS	Quartile	III,IV	0.799	0.303	<.001	62	view →
GBM	DFS	Quartile	All	0.845	0.617	.011	9	view →
UCEC	DFS	Median	III,IV	0.494	0.905	.044	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CABLES1–PDAC (DFS)

Open the PDAC breakdown →