CABLES1

Across TCGA patient cohorts, CABLES1 mutation is significantly associated with the RNA expression of many other genes, with 1,839 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CABLES1-associated genes across cancer lineages are MIR3140, RNY1P8, and KRT33A. Each is linked with CABLES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CABLES1-to-partner and partner-to-CABLES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3140 grouped by CABLES1-low versus CABLES1-high in KIRP.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CABLES1→partner) and Y-score (partner→CABLES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	MIR3140 →	+0.238	+4.770	<.001	.006	3	2
UCEC	RNY1P8 →	+0.276	+2.951	<.001	.007	3	2
SCLC	KRT33A →	+0.106	+4.502	<.001	.004	3	1
UCEC	BTBD10 →	+0.534	+2.337	<.001	.003	3	1
UCEC	LIN7C →	+0.526	+2.743	.005	.002	3	1
UCEC	PGAP2 →	+0.545	+3.922	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,839 associations by consensus.

MIR3140 by CABLES1 expression — KIRP

Explore this box plot interactively →