CABLES1

Across TCGA cell cohorts, CABLES1 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CABLES1-associated genes across cancer lineages are SEC14L3, TULP2, and CWH43. Each is linked with CABLES1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CABLES1-to-partner and partner-to-CABLES1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC14L3 grouped by CABLES1-low versus CABLES1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CABLES1→partner) and Y-score (partner→CABLES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEC14L3 →	+0.024	+2.672	<.001	.004	3	1
LARGE_INTESTINE	TULP2 →	+0.132	+2.745	<.001	.007	3	1
LARGE_INTESTINE	CWH43 →	+0.617	+3.302	.004	.008	3	1
LARGE_INTESTINE	STK11 →	+0.714	+3.215	.001	.009	3	1
CNS	FAM170B →	+0.135	+4.981	<.001	.008	3	1
CNS	SPATA31A5 →	+0.022	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

SEC14L3 by CABLES1 expression — LARGE_INTESTINE

Explore this box plot interactively →