CAB39L

Across TCGA pan-cancer cohorts, CAB39L RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CAB39L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CAB39L RNA is repressed in tumor relative to normal tissue. In most cancer types CAB39L is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where CAB39L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAB39L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−1.559	<.001	12	view →
KIRC	Male	II,III,IV	−1.531	<.001	12	view →
THCA	Male	III,IV	−1.498	<.001	11	view →
KICH	All	II,III,IV	−1.509	<.001	10	view →
LUAD	Female	III,IV	−1.671	<.001	9	view →
KIRP	Male	All	−1.186	<.001	8	view →
LUSC	Female	II,III,IV	−2.472	<.001	7	view →
STAD	Female	All	−2.052	<.001	7	view →
BLCA	All	All	−1.099	.002	7	view →
UCEC	All	All	−2.166	<.001	6	view →
BRCA	Female	II,III,IV	−1.213	<.001	6	view →
CHOL	All	All	+1.911	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CAB39L–HNSC

Open the HNSC breakdown →