CAB39L

Across TCGA pan-cancer cohorts, CAB39L mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CAB39L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CAB39L mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CAB39L is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where CAB39L tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAB39L mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−1.819	<.001	12	view →
CCRCC	Male	III,IV	−0.738	<.001	12	view →
LSCC	Male	All	−1.683	<.001	9	view →
LUAD	Male	III,IV	−1.201	<.001	9	view →
COAD	Male	II,III,IV	−1.171	<.001	9	view →
PDAC	Female	II,III,IV	−0.785	<.001	5	view →
OV	All	All	−1.494	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CAB39L–HNSC

Open the HNSC breakdown →