CA6

Across TCGA patient cohorts, CA6 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA6-associated genes across cancer lineages are ATM, eIF4E, and JNK_pT183_Y185. Each is linked with CA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA6-to-partner and partner-to-CA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CA6-low versus CA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA6→partner) and Y-score (partner→CA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.715	-2.986	.001	.035	3	2
UCEC	eIF4E →	+0.213	+2.321	.044	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.239	-2.308	.004	.036	3	1
UCEC	JNK2 →	+0.345	+2.321	<.001	.035	3	1
UCEC	p62 Lck ligand →	+0.389	+3.459	.017	.005	3	1
UCEC	p70-S6K →	+0.196	+2.348	.043	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by CA6 expression — UCEC

Explore this box plot interactively →