CA5B

Across TCGA cell cohorts, CA5B mutation is significantly associated with the mutation status of many other genes, with 208 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CA5B-associated genes across cancer lineages are TMEM70, PRPH2, and IDH3G. Each is linked with CA5B in more than 1 cancer types. Because this analysis shows association rather than direction, both CA5B-to-partner and partner-to-CA5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM70 grouped by CA5B-low versus CA5B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA5B→partner) and Y-score (partner→CA5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM70 →	+4.523	+5.087	.006	.006	1	2
OVARY	PRPH2 →	+4.977	+4.415	.007	.007	1	2
LARGE_INTESTINE	IDH3G →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	PCGF1 →	+5.523	+5.523	.003	.003	1	2
LARGE_INTESTINE	SYF2 →	+5.523	+5.523	.003	.003	1	2
OVARY	C8orf34 →	+4.977	+4.415	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 208 associations by consensus.

TMEM70 by CA5B expression — LARGE_INTESTINE

Explore this box plot interactively →